Μοντέλα μετά-ανάλυσης και εφαρμογές στην επιδημιολογία
Meta-analysis models and their applications to epidemiology data
KeywordsΕτερογένεια ; Μετα-ανάλυση ; Συστηματική ανασκόπηση ; Μοντέλο σταθερών επιδράσεων ; Μοντέλο τυχαίων επιδράσεων ; Ανάλυση υποομάδων ; Σφάλμα δημοσίευσης ; Επιδημιολογία
In this paper we have described the role and the value of Meta-Analysis in the medical society and we have given detailed examples of all the steps of the Systematic Review from the published work of Gioxari, Kaliora, Marantidou and Panagiotakos (2017). Special emphasis was placed on the rules of the performance of the Systematic Review, and we have shown a step by step search process of Randomized Clinical Trials on the Pubmed database. In our paper we have described the Types of Clinical Trial Bias, how they are evaluated and how they ultimately affect Meta-Analysis. Subsequently, we have described the assumptions of the Fixed Effects model in mathematical terms and we applied it using the programming language R. We have also discussed the problem of detecting and addressing Heterogeneity in Meta-Analysis, giving appropriate examples from the Random Effect Model and Analysis in Subgroups. Finally, we discussed the existence of the Publication Bias in the scientific community and the ways of its assessment and handling.