This paper tries to scrutinize the relationship between Greece and the United States of America by using as a primary tool American Studies Master’s program. It analyses elements that affect this relation starting by a historic overview and continues further by estimating the current level of the Greek-US relationship. It traces, studies and assesses various levels of that interaction in a contemporary context, as well as tries to monitor drivers of change that lead the way to the future. In this context, the goal is to pursuit a general view about their prospect, to deduce proposals and useful conclusions for further enhancement.