Negotiations have penetrated individual and public life in various aspects and degrees, influencing both personal and professional level. Diversion including different cultures, ages and genders has infiltrated the corporate world, changing the game and adding new players. In a quick-paced, more global however regional-focused environment than ever before, business negotiations constitute of an effective, high-risk and high-reward tool into achieving one‟s targets. The role of emotions and their effect on business negotiations will be analysed in the present Thesis. Thought process, emotional state, interaction and behavior will be decomposed with relation to genders, leadership styles, strategies and communication tactics. Methods used are literature, frameworks, personal and shared experience as well statistics. Findings of this Thesis include direct psychosomatic differentiations based on gender and situation, as well their effect on negotiation strategies. Conclusion biological indicators influencing behaviour, their use and implementation at the negotiation table as part of an integrated strategy into achieving required outcome.